PTGS2 and cancer: Furthermore, the n-3 LC-PUFA pattern, which has pleiotropic effects and enhances cancer cell apoptosis, modulates various eicosanoid pathways, leading to reduced inflammation, such as suppressing cyclooxygenase-2 synthesis inhibiting arachidonic acid-derived eicosanoids (Mauermann, Pouliot & Fradet, 2011).