The common variance between TNF receptor1, TNF receptor2, osteoprotegerin, and osteopontin was explained by the factor “Inflammation”, the common variance between copeptin, and MR-proADM was explained by the factor “Oxidative Stress”, and the common variance between endostatin, galectin 3, TIMP 1, cathepsin S, GDF-15 and MMP-1 was explained by the factor “Fibrosis”. Here, SPP1 is linked to fibrosis.