In addition, while MNK inhibitors did not affect LAG3 expression in tumor-infiltrating CD8+ T cells in both the KPC-344 and the TBP-3868 tumors, MNK inhibitors increased TIM3 levels in tumor-infiltrating CD8+ T cells only in the KPC-344 tumors (Supplemental Figure 4). The gene discussed is ATP7A; the disease is neoplasm.