Notably, while we were able to identify a negative correlation between MKNK2 and TAM M2 markers (CD163, MRC1) in the TCGA PDAC data set, this correlation was absent in the TCGA breast carcinoma data set, further highlighting the differences in tumor tissues likely accounting for the observed difference in TAM phenotype following MNK inhibition in pancreatic tumors compared with breast tumors. This evidence concerns the gene MRC1 and breast carcinoma.