Using deep, targeted amplicon sequencing of the most common gene mutations found in DLBCL (n = 57 genes; Supplemental Figure 8), we observed recurrent mutations, including SGK1 (P < 0.001), MYC, CD83, CD70 (P < 0.01), PIM1, HIST1H1E, and ZFP36L1 (P < 0.05) in PRAME-positive cases. Here, SGK1 is linked to diffuse large B-cell lymphoma.