Given that a direct interaction of PRAME with PRC2 has been previously shown in HEK293 cells (34), we tested PRAME-EZH2 interaction across a spectrum of DLBCL-derived cell lines and confirmed direct protein interaction irrespective of EZH2 mutation status, which is consistent with a function of PRAME as a negative regulator of PRC2. The gene discussed is PRAME; the disease is diffuse large B-cell lymphoma.