COL1A1 and Hepatic fibrosis: Notably, as a consequence of chronic liver damage, 5-month-old PTEN/SCAPΔL mice exhibited severe liver fibrosis, nearly cirrhosis, accompanied by a significant increase in type 1 collagen α1 (Col1a1) mRNA (Figure 2, B and C), whereas PTENΔL and SCAPΔL mice showed only very mild fibrosis at the same age.