Consistent with their altered functional response and recent reports (24, 25), we observed decreased expression of genes related to key immune pathways, such as antigenic presentation, innate immune responses and MAPK and NF-κB signalling (JUNB, ATF3, NFkB2) in monocytes from patients suffering from severe COVID-19 (Figure 6B). This evidence concerns the gene NFKB2 and COVID-19.