Consistent with their altered functional response and recent reports (24, 25), we observed decreased expression of genes related to key immune pathways, such as antigenic presentation, innate immune responses and MAPK and NF-κB signalling (JUNB, ATF3, NFkB2) in monocytes from patients suffering from severe COVID-19 (Figure 6B). The gene discussed is NFKB1; the disease is COVID-19.