Fucosylation impacts microbial metabolism, and mutations in galactoside 2-alpha-L-fucosyltransferase 2 (FUT2), which catalyzes addition of fucose in α1,2 linkage to Gal at non-reducing ends of glycans, have been linked to susceptibility to IBD.83 This has widespread implications for a large subset of the population who are “non-secretors” (i.e., lacking a functional FUT2 enzyme). This evidence concerns the gene FUT2 and inflammatory bowel disease.