Interestingly, MUC2 glycosylation has shown to enhance IL-8 production by dendritic cells and neutrophil recruitment in vitro, 126 which points to a possible proinflammatory role that may compete with immunoregulatory functions; however, this MUC2 was derived from the colorectal cancer-line LS174T,126 so whether this effect is due to a cancer-associated carbohydrate-specific activity, and its role in vivo, remains to be determined. The gene discussed is MUC2; the disease is cancer.