On the contrary, in locally advanced pancreatic NETs, which are considered unresectable due to vascular invasion, exhibiting Ki-67 ≤10%, SSTR expression, and fluorodeoxyglucose (FDG)-PET positivity (SUVm 5-7) as well, chemotherapy would seem adequate to target resectability (consensus, 88%). The gene discussed is MKI67; the disease is pancreatic neuroendocrine tumor.