TP53 and cancer: Therefore, it is not surprising that inactivating TP53 mutations have been implicated in the carcinogenesis of a multitude of malignancies, with GEAs being no exception.10 In fact, the Asian Cancer Research Group (ACRG) included TP53 expression as part of their proposed molecular classification of GC.11 Using gene expression panels derived from 300 GCs, the ACRG first separated GCs molecularly into 2 large categories: MSI and microsatellite stable (MSS).