7 However, TP53 is the most frequently altered gene with approximately 50% of GEAs and 70% of CIN GCs harboring mutations.6,8TP53 encodes the tumor suppressor p53 protein that functions as a key member of the G1/S checkpoint to help maintain genetic integrity through the cell cycle.9 In times of cellular stress TP53 expression increases to mediate G1 phase cell cycle arrest to facilitate repair before cellular division or promote apoptosis in cells with an overabundance of molecular derangements that cannot be overcome. The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.