CRP and obesity due to melanocortin 4 receptor deficiency: SNVs within ENPP1 are associated with traits relevant to metabolic syndrome (blood phosphate measurement and c-reactive protein measurement) (Buniello et al. 2019), cardiovascular diseases (Bacci et al. 2011), obesity, increased risk of glucose intolerance and type 2 diabetes in humans (Meyre et al. 2005).