Furthermore, a recent review of prospective cohort studies and short-term trials (13) suggests that regular consumption of SSBs was associated with hyperuricemia and gout, which could further increase the risks for T2DM, CVD, and MetSyn, in addition to dyslipidemia (13, 88), inflammation (13, 89), and decreased leptin (90). The gene discussed is LEP; the disease is gout.