However, the PPARγ agonists rosiglitazone or 15d-PGJ2 effectively decreased CRE, BUN, and blood glucose levels in the PF model rats, while PPARγ antagonist GW9662 caused no significant changes of CRE, BUN, and blood glucose contents in the model rats (Fig. 1A–C). The gene discussed is PPARG; the disease is pemphigus foliaceus.