We reported in our previous study on dysregulation of apoptosis related genes in neutrophils of patients with GPA (down regulation of PMAIP1, DIABLO, CASP3, CASP7, BAX, RUNX3, E2F1, TP53 and up-regulation of CFLAR, BCL2A1) [28]. The gene discussed is E2F1; the disease is granulomatosis with polyangiitis.