MPO and granulomatosis with polyangiitis: In patients with active GPA level of circulating DNA-MPO complexes correlated with BVAS (r = 0.64, P < 0.05, Fig. 5B) and EVs expression of miR-664a-3p (r = 0.76, P < 0.05, Fig. 5C) and miR-223-3p (r = 0.55, P < 0.05, Fig. 5D).