NF-κB-mediated inflammation also leads to the upregulation of the ubiquitin ligases MuRF1 and atrogin-1 that are known to be involved in myostatin- or activin A-induced skeletal muscle atrophy by increasing protein degradation and inhibiting protein synthesis (Wysong et al., 2011). The gene discussed is NFKB1; the disease is Skeletal muscle atrophy.