AEs of special interest, includingbradyarrhythmia at treatment initiation, hypertension, and VZV, were also in linewith the core part and other S1P modulators, particularly fingolimod.31 There was one case of CM in the extension part up to the data cutoff and noreported cases of PML. This evidence concerns the gene MBTPS1 and cutaneous mastocytosis.