FBXL17 and medulloblastoma: In SHH medulloblastoma, the substrate adaptor F-box/LRR-repeat protein 17 (Fbxl17) assembles into a functional SCFFbxl17 to promote the ubiquitylation-dependent degradation of the tumour suppressor Suppressor of fused homologue (SUFU), acting as a bona-fide oncoprotein [4].