NPM1 and acute myeloid leukemia: The AML subgroup identified by Papaemmanuil et al.27 as the NPM1 mutation genomic group (418 patients, 27%) matches well with the co-mutation patterns in our network: NPM1, DNMT3A, FLT3,ITD TET2 and PTPN11. There were 275 (18%) samples with mutated chromatin and RNA splicing27.