Since DEspR’s ADAR1 RNA-edited transcript18 is not discernable in scRNA-sequencing limited to 300 nucleotides from the poly-A sequence of each transcript to ascertain specificity and equivalent representation, we studied the DEspR-pathway gene network (DEspR’s modulators, ligands, and downstream function-marker) represented in the scRNA-seq data files of immune cells and epithelial cells in nasopharyngeal and broncho-lavage fluid samples from COVID-19 subjects12: healthy control (n = 5), mild (n = 8) and severe (n = 11) COVID-19 patient samples. The gene discussed is ADAR; the disease is COVID-19.