Confirmatory IF-staining detected intra-alveolar and interstitial DEspR+CD11b+ neutrophils and macrophages in ARDS (Fig. 2I, Supplementary Fig. S2A) and COVID-19-ARDS (Fig. 2J, Supplementary Fig. S2B) lung tissue sections, as well as DEspR+MPO+ neutrophils and macrophages in COVID-19-ARDS lung tissue section (Fig. 2K, Supplementary Fig. S2C). Here, FBXW7-AS1 is linked to acute respiratory distress syndrome.