We used a recombinant, humanized anti-DEspR antibody, cross reactive to human, monkey and rodent DEspR, with a hinge-stabilized [S228P]IgG4 backbone, hu6g8, developed by us and validated for detection of DEspR-specific cell expression, and in vitro and in vivo DEspR-inhibition resulting in apoptosis in DEspR+ tumor cells and cancer stem-like cells18. The gene discussed is FBXW7-AS1; the disease is cancer.