EDN1 and acute respiratory distress syndrome: To dissect the differential pattern emerging between survivors and non-survivors (Fig. 4F,G), we first performed correlation matrix analysis on a panel of DEspR-based flow cytometry markers, clinical markers of ARDS severity, and plasma biomarkers associated with neutrophil-mediated secondary tissue injury, and ET1 one of two DEspR ligands (Fig. 5A, Table 1).