Data from multiple experimental systems among multi-center collaborators testing neutrophils in whole blood samples, either from NHVs, ARDS or COVID-19-ARDS patients, or Rhesus macaques, reproducibly identify the DEspR+ CD11b+ neutrophil-subset, concordant with cumulative evidence for neutrophil heterogeneity1,48. This evidence concerns the gene ITGAM and acute respiratory distress syndrome.