Thus, given the importance of those factors in the metabolism and obesity, as well as in the progress of a neurodegenerative environment, a deeper investigation of the central mechanisms of energy balance, and cognitive function in our model is needed in order to elucidate how peripheral metabolic and immunomodulatory events promoted by absence of mGluR5, may modulate these central highpoints. The gene discussed is GRM5; the disease is obesity due to melanocortin 4 receptor deficiency.