Analyzing Vps4b and Rnf31 in melanoma and breast cancer cell lines, moreover, indicate a partial conservation of this phenotype in other cancer entities, with loss of Rnf31 also sensitizing B16 melanoma cells to CTL killing and loss of Vps4b leading to a trend towards higher sensitivity in EO771 breast cancer cells (Fig. 3d). The gene discussed is VPS4B; the disease is breast carcinoma.