Results of this study suggest that Rnf31, as part of the linear ubiquitination chain assembly complex (LUBAC), mediates immune-escape by stabilizing anti-apoptotic proteins in the TNF pathway, and that Vps4b, as part of the autophagy machinery, reduces susceptibility to T cell-mediated tumor cell lysis by lowering intracellular granzyme B contents. Here, RNF31 is linked to neoplasm.