INS and diabetes mellitus: Whereas genetic reduction of GLUT2 specifically in RPTCs did not affect the susceptibility of the mice to develop insulin deficient diabetes (Fig. 7a–e), the null mice exhibited increased glycosuria (Fig. 7f) and preserved kidney function, manifested by reduced kidney-to-body weight ratio, urine excretion-to-water consumption ratio, as well as reduced proteinuria, albuminuria, urine creatinine, ACR, and urinary KIM-1 (Fig. 7g–m), without affecting BUN or CCr (Fig. 7n, o).