Nevertheless, the Akita-RPTC-CB1R−/− mice were protected from the deleterious effects of hyperglycemia on their kidneys, exhibiting reduced kidney-to-body weight, urine exertion-to-water consumption, and albumin-to-creatinine (ACR) ratios, reduced proteinuria, albuminuria, and urinary excretion of kidney injury marker 1 (KIM1), as well as improved creatinine clearance (CCr; Fig. 1a–g). Here, HAVCR1 is linked to Hyperglycemia.