In fact, inhibiting its activity by DO34 in HG-treated hRPTCs normalized the elevated GLUT2 protein levels (Fig. 2u, v), suggesting a vicious cycle by which hyperglycemia induces CB1R reactivation by 2-AG production and subsequently increases GLUT2 expression through activation of the CB1R/mTORC1 signaling pathway. Here, CNR1 is linked to Hyperglycemia.