CD274 and neoplasm: It should be noted that while the affinity of ALPN-202 for PD-L1 is significantly higher than WT CD80, the KD is lower than that of therapeutic PD-1 and PD-L1 antibodies42 and more experiments are required to evaluate the relative potency of ALPN-202 to block the PD-1–PD-L1 interaction in humanized in vivo tumor models.