TGFB1 and colorectal carcinoma: These changes culminate in an immunosuppressed, pro-growth ecology that supports a higher abundance of tumor cells (CK) in CRC, having significantly less inflammation (TNF-α and CD8) and more pro-tumor factors, including macrophages (CD68), TGF-β, and vasculature (CD31) as compared to benign adenomas (CRA).