WSB1 and cancer: Here, we were particularly interested in one of the DAP3 target genes, WSB1 (WD repeat and SOCS box-containing protein 1) which is an E3-ubiquitin ligase that promotes ATM ubiquitination and degradation to drive tumorigenic progression20, with the following reasons including (1) differentially spliced-in tumors of multiple cancer types (Fig. 6a), (2) lower PSI value in tumors predicts poor prognosis (Fig. 6b), and (3) hypothetically, its expression can be affected by DAP3 via AS-NMD (Fig. 7a).