We semi-quantitatively evaluated 4EBP1 staining intensity and correlated 4EBP1 immunoreactivity with the NB histological subtypes according to the International Neuroblastoma Pathology Classification (INPC), which distinguishes patients with favorable or unfavorable histology based on grade of neuroblastic differentiation and mitosis-karyorrhexis index. The gene discussed is EIF4EBP1; the disease is neuroblastoma.