Overexpression of EIF4EBP1 in cancer is mediated by certain transcription factors, such as MYC [36, 37], androgen receptor [38], and the stress regulators ATF4 [39] and HIF-1α [40], which all bind to and thereby modulate the activity of the EIF4EBP1 promoter. The gene discussed is EIF4EBP1; the disease is cancer.