Human exome sequencing and genome-wide association studies have linked mutations in genes encoding subunits of the SWI/SNF complex, including Brm and Brg1 to neurodevelopmental disorders such as the Coffin-Siris syndrome53–55, Nicolaides-Baraitser syndrome56, autism spectrum disorder57, and schizophrenia58. The gene discussed is SMARCA2; the disease is neurodevelopmental disorder.