CDKN2B-AS1 and cancer: For example, circulating lncRNA SOX2OT and ANRIL, which were markedly overexpressed in the serum of patients with NSCLC, have been evaluated as ideal biomarkers for diagnosing NSCLC and predicting the overall survival rate of NSCLC patients, yielding superior sensitivity and specificity with remarkable potential in distinguishing patients with cancer from controls [104].