Several studies have indicated that mitochondrial reactive oxygen species (ROS) play a significant role in controlling tumour growth as crucial upstream regulators to trigger NLRP3 inflammasome activation and subsequent pyroptosis, wherein the signal transduction of ROS generation requires the involvement of NF-κB pathway, which increases the expression of NLRP3 and pro-caspase-1 proteins [87]. Here, NLRP3 is linked to neoplasm.