A study by Xu et al. reported that the lncRNA XIST had a positive impact on the resistance of NSCLC cells to DDP by directly interacting with SMAD2 and reducing its nuclear translocation, thus inhibiting cell pyroptosis via blockage of NLRP3 activation along with downregulated cleaved caspase-1, IL-1β, IL-18 and cleaved GSDMD [39]. This evidence concerns the gene SMAD2 and non-small cell lung carcinoma.