A study by Xu et al. reported that the lncRNA XIST had a positive impact on the resistance of NSCLC cells to DDP by directly interacting with SMAD2 and reducing its nuclear translocation, thus inhibiting cell pyroptosis via blockage of NLRP3 activation along with downregulated cleaved caspase-1, IL-1β, IL-18 and cleaved GSDMD [39]. The gene discussed is IL18; the disease is non-small cell lung carcinoma.