PARP1 and non-small cell lung carcinoma: Studies have demonstrated that the lncRNA NEAT1 may contribute to paclitaxel resistance of NSCLC by suppressing apoptosis via activating Akt/mTOR signalling, with downregulation of cleaved PARP, cleaved caspase-3 and Bax proteins while upregulation of Bcl-2 (ref. [41]).