BCL2 and non-small cell lung carcinoma: In addition, PVT1 is associated with radiotherapy resistance in NSCLC, and its knockdown promoted apoptosis owing to Bax upregulation and Bcl-2 downregulation and elevated the radiosensitivity of NSCLC cells by competitively binding to miR-424-5p to modulate CARM1 expression [61].