TNFRSF18 and hepatocellular carcinoma: Among the LIHC samples (N = 342), the overall survival of the GITRL high-expression group (N = 189) was significantly lower than that of the low-expression group (N = 153, P = 0.039, Fig. 2B), and that of the GITR high-expression group (N = 104) was also significantly lower than that of the low-expression group (N = 238, P = 0.012, Fig. 2B), suggesting the increased GITRL or GITR expression is correlated with HCC disease severity and poor clinical outcome.