BTK, a tyrosine kinase and a key regulator of the BCR (B-cell receptor) pathway, is up-regulated in a variety of lymphoma cells.72 GSPT1, a translation termination factor, is involved in regulation of mammalian cell growth.73 Interestingly, GBD-9 retains the characteristics of both a PROTAC and a molecular glue.71 The designer balanced the activities of PROTACs and molecular glues by modulating the length of the linker of BTK PROTACs. Here, BTK is linked to lymphoma.