In contrast, excess Mical along with Tau resulted in significant memory impairment (Fig. 6d, ANOVA: F(3,53) = 7.8466, p = 0.0002; subsequent LSM: p = 0.00015 and p = 0.0067 0N3RMical vs control and Mical transgene respectively). This evidence concerns the gene MICAL1 and memory impairment.