For instance, under pathological conditions such as sepsis macrophages can release Exo with the ability to increase the expression of intercellular adhesion molecule-1 (ICAM-1) in alveolar epithelial cells and trafficking of immune cells from the blood side into the pulmonary niche, leading to subsequent tissue damage and deleterious outcomes [16, 17]. This evidence concerns the gene ICAM1 and Sepsis.