It should also be noted that in CDD there are more variants of CD combinations, for example the “basic” four CDs of ORF 1 may be combined with Orbi_VP1 or with SANT and even with three or more domains, including ribosomal_S8e_like (For example, GenBank: XP_026441742.1, TYK17964.1), but investigation of all CDA variants is beyond the scope of the present research. Here, CDA is linked to craniodiaphyseal dysplasia.