The standardized extract of green propolis EPP-AF has already demonstrated protective efficacy in an experimental model of sepsis, with evident contributions to the protection of glomerular filtration and tubular function, reduction of cytokines and macrophage infiltration in renal tissue, immunoregulation of TLR4 and NF-κB, and reduction of lung inflammation [17]. The gene discussed is TLR4; the disease is atrial fibrillation.