SPARCL1, Fibrinogen alpha chain precursor, Serum amyloid A-1 protein (SAA1), Amyloid β A4 precursor protein (APP), Amyloid-like protein 1 (APLP1), and Apolipoprotein E (APOE) precursor levels were different in patients with JE compared with control group (Fig. 2A, Additional file 2: Fig. S2D, F, Additional file 3: Fig. S3C, D, Additional file 9: Table S3). This evidence concerns the gene APP and Japanese encephalitis.