MADCAM1 and colitis: In mice with colitis treated with a monoclonal antibody against MAdCAM-1, the number of rolling leukocytes along cerebral endothelial cells was also significantly reduced (Fig. 3E, F, Additional file 3), and a tendency for a reduction in adherent leukocytes was also observed (Fig. 3E; Colitis + IgG2a: 1.6 ± 0.4 cells/100 μm/min; colitis + anti-MAdCAM-1: 0.7 ± 0.3 cells/100 μm/min; t = 1.8, df 9, P = 0.11).