ITGA8 and coinfection: To make sure the results of proteomics, eight integrins, including ITGα1, ITGα3, ITGα5, ITGα6, ITGα8, ITGα9, ITGα11 and ITGβ3 that altered significantly in the co-infection group compared to each monoinfection group, were choose for qRT-PCR analysis with primers in Table 1.