In addition, the CK14+ tumor cells are found to be enriched in desmosome and hemidesmosome adhesion complex genes, co-expressed effector molecules of metastasis such as Epiregulin (Ereg), Tenascin C (Tnc), Jagged1 (Jag1) that are collectively involved in niche modelling and are deficient in major histocompatibility (MHC) class II genes, indicating a low immunogenic profile [57]. The gene discussed is JAG1; the disease is neoplasm.