This model is based on an established equilibrium between polymorphism frequency in human and that of parasite strains due to competition between strains preferring binding on either ICAM-1Kilifi or ICAM-1ref, the change in host in allele frequency will favor the expansion of the corresponding high binding parasite strains which will select in return against the most frequent allele in host bringing the system to equilibrium at which all individuals will have the same risk of developing severe or cerebral malaria irrespective of their ICAM-1 genotype [38]. Here, ICAM1 is linked to cerebral malaria.