Patients with thyrotoxicosis showed a worse hazard ratio for mortality compared to those in the no thyroid irAE group, although the difference between the two groups was not statistically The TPO Ab positivity and the Tg-Ab positivity did not show a statistically significant difference between the thyroid irAE and no thyroid irAE groups (p = 0.099 for TPO-Ab and 0.591 for Tg-Ab) (Tables 4 and 5). The gene discussed is TPO; the disease is thyrotoxicosis.