With the adoption of a cut-off value of 1957 pg/mL, ADAMDEC1 in the synovial fluid was able to discriminate RA patients from OA patients with an AUC value of 0.951, a specificity of 88.6%, and a sensitivity of 92.9% (Fig. 2b). The gene discussed is ADAMDEC1; the disease is rheumatoid arthritis.