The concentration of TGF-β3 was 3.81 ± 1.64 pg/ml in AH samples of the DMC group and 3.35 ± 1.61 pg/ml in AH samples of the ARC group; however, the differences between the two groups were not statistically significant (P value = 0.249) (Fig. 1c). This evidence concerns the gene TGFB3 and Dyggve-Melchior-Clausen disease.