Among them, PCNA, HMGB1, OGG1, SMUG1, and XRCC1 showed a direct network relationship with the progress of CIN, and ATM, ABCG2, TDG, LIG1, FEN1 and CIN progression showed an indirect network relationship. The gene discussed is HMGB1; the disease is cervical squamous intraepithelial neoplasia.