Early warning of the progress of CIN was observed for HMGB1, LIG1, ABCG2, TDG, and PCNA with an AUC of 0.74, 0.68, 0.67, 0.65, and 0.65 (P < 0.05). Here, HMGB1 is linked to cervical squamous intraepithelial neoplasia.