In particular, ATM and 11 genes related to CIN progression (TP53, TP63, EGFR, ERBB2, PIK3CA, CDKN2A, CTNNB1, FHIT, MYC, STK11, TP53BP1) interacted directly; PCNA and 10 genes related to CIN progression Genes (CDKN2A, TP53, EGFR, MYC, CCL2, ERBB2, MKI67, CTNNB1, FHIT, TP53BP1) interacted directly; ABCG2 and 5 genes related to CIN progression (CTNNB1, EGFR, ERBB2, MYC, TP53) interacted directly; MDK and 5 genes related to CIN progression (MAPK1, TP53, ERBB2, PIK3CA, EGFR, MYC, PTGS2) interacted directly. The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.