Through ROC curve analysis, we found that the genes that were valuable for early warning of CIN occurrence and progress were OGG1 and HMGB1 and HMGB1, LIG1, ABCG2, TDG, and PCNA, and the gene with value for early warning of CIN occurrence and progress was HMGB1. This evidence concerns the gene LIG1 and cervical squamous intraepithelial neoplasia.