Among them, PCNA, HMGB1, OGG1, SMUG1, and XRCC1 showed a direct network relationship with the progress of CIN, and ATM, ABCG2, TDG, LIG1, FEN1 and CIN progression showed an indirect network relationship. This evidence concerns the gene OGG1 and cervical squamous intraepithelial neoplasia.