Combined with the literature search, 10 candidate differential genesrelated to CIN and cervical cancerwere initially screened: ATM, ABCG2, PCNA, XRCC1 HMGB1, OGG1, LIG1, SMUG1, FEN1, and TDG. The gene discussed is XRCC1; the disease is cervical squamous intraepithelial neoplasia.