Furthermore, the pair wise SNP associations observed between one of the SNPs of the present study (rs7582720 of WDR12 gene on chromosome2) and three SNPs of 11q23.3 region (belonging to ZPR1, APOA5-APOA4 and, BUD13 genes) also suggested unique epistatic interactions of SNPs in CAD pathology. This evidence concerns the gene WDR12 and coronary artery disorder.