The pair wise interaction analysis suggested that the rs7582720 of WDR 12 gene on chromosome 2, albeit not individually associated with CAD, was found to be significantly conferring risk through epistatic interaction with the two SNPs (rs6589566, rs1263163) of 11q23.3 region which were found to be located in ZPR1 gene and intergenic region of APOA5-APOA4 genes respectively (Table 6). The gene discussed is ZPR1; the disease is coronary artery disorder.