The additional risk conferring SNPs of angina, ACS and MI categories were found to be located in FADS1, SMARCA4 and GALNT2 genes respectively and encode for proteins with diverse functional roles like lipid metabolism, chromatin remodelling and oligosaccharide biosynthesis suggesting that the unique set of SNPs associated with the phenotypic severity categories of CAD belonged to diverse functional pathways. This evidence concerns the gene SMARCA4 and angina pectoris.