EGFR and cancer: Furthermore, the results of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that several down-regulated genes in Over-HLA cells are significantly enriched in cancer-related pathways such as cytokine-cytokine receptor interaction (P = 3.80 X 10–6), pathways in cancer (P = 8.10 X 10–3), the JAK/STAT signaling pathway (P = 1.40 X 10–2), the ErbB signaling pathway (P = 2.50 X 10–2), Basal cell carcinoma (P = 3.30 X 10–2) and Hedgehog signaling pathway (P = 3.40 X 10–2) (Table 2 and Table S4).