MAPK3 and gastric cancer: In the present study, we found that the protein levels of phosphorylated ERK-1/2 and the ratio of p-ERK-1/2/ERK-1/2 were both significantly decreased after ThPOK overexpression or STPG1 upregulation in gastric cancer cells, which indicated that ThPOK and STPG1 exerted inhibitory effects on the ERK signaling pathway.