Sharma et al. [30] conducted an immunohistochemical analysis of Tregs in the affected sinonasal tissues and found a large number of both CD25+ FOXP3+ and CD4+ FOXP3+ cells in the CRSwNP group than in the CRSsNP group (p < 0.05). This evidence concerns the gene CD4 and chronic rhinosinusitis with nasal polyps.