NFE2L3 and melanoma: In multivariate analysis, the immunohistochemical expression of NRF3 in the cytoplasm of melanoma cells was a more significant predictor of poor melanoma-specific survival than Breslow thickness, but again only in the patients with nodal metastases at the time of diagnosis (for NRF3: hazard ratio (HR) 3.179, 95% confidence interval (CI) 1.065-9.493, p = 0.038, and for Breslow: HR 1.021, 95% CI 0.978-1.067, p = 0.345, respectively).