Here, we continue to describe the immunohistochemical expression and the prognostic role of NRF3 in a sample set of melanomas, their lymph node metastases, and benign and dysplastic naevi with the addition of NRF3 mRNA expression in three Gene Expression Omnibus (GEO) datasets and The Cancer Genome Atlas sample sets from the TIMER2.0 web server [18]. The gene discussed is NFE2L3; the disease is melanoma.