Numerous studies have shown that promoting autophagy could reduce the progression of AMD through various signaling pathways, such as the PI3K/protein kinase B (Akt)/mTOR pathway [34], the AMPK/mTOR pathway [35], and the SQSTM1/Keap1/Nrf2 pathway [36]. The gene discussed is AKT1; the disease is age-related macular degeneration.