Integrins, however, do not operate in isolation, and tumor growth and invasion depend on integrin crosstalk with growth factor-, chemokine- and non-integrin adhesion receptors, including syndecans (see 3.1 below) expressed on both tumor cells and stromal cells (Desgrosellier and Cheresh 2010; Thomas et al. 2019). The gene discussed is SDC1; the disease is neoplasm.