In the present study, however, the levels of serum albumin before and after preoperative CRT were not significantly different between the early recurrence group and the others (early recurrence vs. others before and after preoperative CRT: 4.0 and 3.9 vs. 3.9 g/dL and 3.9 g/dL; p = 0.384 and p = 0.977, respectively), and the serum CA19-9 level before surgery > = 56.8 U/mL was associated with significantly higher rate of early recurrence after surgery even in the presence of hypoalbuminemia. This evidence concerns the gene ALB and Hypoalbuminemia.